CreatripTeam

A 32-year-old woman in Vietnam sought gynecological care for reproductive issues and was diagnosed with complete androgen insensitivity syndrome (AIS), a rare genetic condition where an individual has male chromosomes (46,XY) but the body cannot respond to male hormones (androgens). Despite fully female external appearance and developed breasts, MRI showed no uterus and two undescended testes in the abdomen. Hormone tests revealed high testosterone levels that the body could not use. Medical teams removed the testes laparoscopically and reconstructed a functional vagina using the patient’s own skin and mucosa; she now receives estrogen therapy to maintain feminine physical traits and endocrine balance. AIS is usually discovered at puberty when expected male changes do not occur. It is inherited in a sex-linked recessive pattern and affects about 2–5 per 100,000 people. Management focuses on psychological support, regular tumor surveillance for undescended testes, and surgical removal of gonads (ideally after puberty) with reconstructive procedures when needed.